at the Department of Materials and Environmental Chemistry.

Closing date: April 20, 2021.

The Department of Materials- and Environmental Chemistry (MMK) with about 140 employees is one of the largest departments at the Faculty of Natural sciences at Stockholm University (SU). The extensive research activities of MMK encompass both the development and characterization of large groups of (functional) materials, such as soft matter and polymers, biomaterials, self-assembled and porous materials, for primarily applications in Materials Science and Sustainable/Green Chemistry. The experimental characterisation techniques involve X-ray and neutron diffraction, electron microscopy, NMR and other spectroscopic techniques, along with modelling by computer simulations. Environmental aspects are an important part of the research activities.

Project description

Project Leader: Prof. Mattias Edén, Email: mattias.eden@mmk.su.se

Efficient drugs for the treatment of diseases are a critical need for society. A crucial step in drug development is to obtain the optimal solid form of the active pharmaceutical ingredient (API), which is challenging because most active pharmaceutical ingredients are able to adopt different solid forms (polymorphs), crystalline as well as amorphous. It is therefore imperative to develop new crystallization methods. Here, ionic liquids (ILs, room temperature molten salts) may offer new opportunities in drug development.

This project is one part of a research program lead by Prof. Anja-Verena Mudring (PI), a world-leader in the field of ionic liquids, which involves several research group at SU with a wide palette of expertise in materials synthesis and characterization.

The postdoc in the project will be responsible for both routine and advanced multinuclear solid-state MAS NMR experimentation, encompassing spins-1/2 as well as half-integer spin quadrupolar nuclei. We particularly aim to (i) identify if the API molecules preferentially associate with the cation or anion IL components, (ii) locating the preferential API/IL binding modes, and (iii) using the insight to steer the crystallization into the most desirable API polymorph.

Duties of the Postdoctoral Researcher

We are inviting a self-motivated and creative individual to apply for a postdoc opening that will primarily involve application of advanced MAS NMR techniques (experimentation involving dipolar recoupling, triple-resonance, and 2D correlation NMR), but also NMR in the solution state. The postdoc will work closely with groups that have expertise in synthesis and materials characterization by diffraction techniques and electron mictroscopy, as well as in computer modeling.

Qualification Requirements

The applicant should have a Ph.D degree in Chemistry (preferred) or Physics (or equivalent), and a well-documented experience with MAS NMR experimentation on inorganic materials, or organic (bio)molecules. The ideal candidate is a self-motivated and creative person with a passion for solving challenging scientific problems.

Selection criteria

The selection will be based primarily on scientific excellence and well-documented experience of applying advanced MAS NMR techniques (dipolar recoupling, triple-resonance, and 2D correlation NMR experimentation) to inorganic and/or organic systems, where previous MAS NMR experience with both is considered particualrly advantageous. Previous experience with MAS NMR of half-integer quadrupolar nuclei, or NMR applied to ILs is considered advantageous, but is not required. Previous experience in solution NMR is desirable but is not required.

Terms of employment

The position involves a fellowship for two years, with possibilities of a further extension. While we would like to fill the position the soonest possible, the starting date is negotiable.

Further Information

For more information, please contact the project leader Professor Mattias Edén, phone +46 8 16 23 75; mattias.eden@mmk.su.se

•  Further information about the Department of Materials and Environmental Chemistry may be found at http://www.mmk.su.se/.

•  Further information about the PI: http://www.su.se/profiles/eden

Application

The application should be submitted by E-mail to: mattias.eden@mmk.su.se, with title [POSTDOCNMR], sent as one single PDF file, and include the following:

•  Cover letter, including description of previous research interests and experience, in particular previous experience with advanced solid-state NMR experimentation on inorganic and/or organic materials.

•  CV, including lists of publications and conference contributions

•  Contact details for 2–3 references (there is no need to upload recommendation letters online)

•  Certificate of Ph.D degree

•  Other documents you want to include.

You are welcome to apply!